Early Bird
pyrantel pamoate sigmaultra
CAS: 22204-24-6
Molecular Formula: C34H30N2O6S
Early Bird - Names and Identifiers
Early Bird - Physico-chemical Properties
| Molecular Formula | C34H30N2O6S |
| Molar Mass | 594.68 |
| Melting Point | 266-267°C |
| Boling Point | 642.7°C at 760 mmHg |
| Flash Point | 356.5°C |
| Solubility | Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol. |
| Vapor Presure | 2.13E-17mmHg at 25°C |
| Appearance | odorless yellowish to yellowish-brown crystalline powder odorless |
| Color | yellow |
| BRN | 9034755 |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00072037 |
| Physical and Chemical Properties | Melting Point: 266 - 267 water-soluble:<0.1g/100 mL at 19 C Appearance: yellow to brown crystalline powder |
| In vitro study | Pyrantel induces Ascaris suum muscle contraction, with a pEC 50 of 7.24. Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle. Pyrantel (72 h) inhibits the survival of Ancylostoma ceylanicum , Necator americanus and Trichuris muris on the third-stage larvae (IC 50 s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC 50 s=>100, 7.6, and 34.1 µg/mL, respectively). |
| In vivo study | Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. |
Early Bird - Risk and Safety
| WGK Germany | 3 |
| RTECS | QL2287000 |
| HS Code | 2934990002 |
Early Bird - Standard
Authoritative Data Verified Data
This product is (E)-1,4,5, 6-tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine -4,4 '-methylene-BIS [3-hydroxy-2-naphthoate]. Calculated as the dried product, the content of C11H14N2S . C23H1606 should be 97.0% ~ 103.0%.
Last Update：2024-01-02 23:10:35
Early Bird - Trait
Authoritative Data Verified Data
- This product is light yellow powder; Odorless.
- This product is slightly soluble in N ,N-dimethylformamide, slightly soluble in ethanol, and almost insoluble in water.
absorption coefficient
operation in the dark. Take about 20mg of this product, precision weighing, add dioxane-0.1% concentrated ammonia solution (1:l )8ml to dissolve, dilute with hydrochloric acid solution (9-1000) to 100ml, shake, filter, take the filtrate with precision, dilute to 50ml with hydrochloric acid solution (9-1000), measure absorbance at the wavelength of 311mn by UV-visible spectrophotometry (General 0401), the absorption coefficient is 302 to 324.
Last Update：2022-01-01 11:33:19
Early Bird - Differential diagnosis
Authoritative Data Verified Data
- take about 10mg of this product, add 5ml of dioxane-0.1% concentrated ammonia solution (1: 1) to dissolve, and add 2ml of dilute hydrochloric acid to form yellow precipitate.
- take about 20mg of this product, add 1ml sulfuric acid, shake, the solution is red.
- in the chromatogram recorded under the content determination, the retention time of the peak of thiamine and the peak of BIS-hydroxynaphthalic acid in the test solution should be consistent with the retention time of the peak of thiazine and the peak of BIS-hydroxynaphthalic acid in the control solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 51).
Last Update：2022-01-01 11:33:20
Early Bird - Exam
Authoritative Data Verified Data
chlorine-containing compounds
take 25mg of this product, according to the oxygen flask combustion method (General rule 0703) for organic destruction, with 0.4% sodium hydroxide solution 10ml as the absorption liquid, once the generated smoke completely inhaled absorption liquid, according to the chloride inspection method (General rule 0801), it should not be more concentrated (0.14%) compared with the control solution made of 3.5ml of standard sodium chloride solution.
bis-hydroxynaphthalic acid
the appropriate amount of BIS-hydroxynaphthalic acid dried under reduced pressure at 60°C for 3 hours was accurately weighed, dissolved and quantitatively diluted with mobile phase to make a solution containing about 52ug per 1 ml, according to the chromatographic conditions under the content determination item, 20ul is injected into the liquid chromatograph with precision, the chromatogram is recorded, and the chromatogram recorded under the content determination item is calculated by the peak area (dried product) according to the external standard method, the Phthalic acid containing bis-hydroxynaphthalic acid should be 63.4% to 67.3%.
Related substances
operation in the dark. New system was applied. Take 80mg of this product, put it in a 100ml measuring flask, add 7ml of mixed solvent of glacial acetic acid-water-diethylamine (5:5:2), dilute it with acetonitrile to the scale, shake well, as a test solution; 1ml was accurately measured, placed in a 100ml measuring flask, diluted to the scale with mobile phase, and shaken to serve as a control solution. According to the chromatographic conditions under the content determination item, 20ul of the control solution and the test solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 4 times of the retention time of the thiazine chromatographic peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:33:20
Early Bird - Content determination
Authoritative Data Verified Data
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using silica gel as filler; Acetonitrile-water-acetic acid-diethylamine (92.8 : 3 : 3: 1.2) as mobile phase; The detection wavelength was 288nm. 10ml of sample solution was taken and irradiated for 24 hours at 2000lx. 20ul of sample was injected into human liquid chromatograph, and the relative retention time of impurity peak immediately after the thiazine peak was about 1.3, the degree of separation of the thiazine peak from the impurity peak should be greater than 4.0.
- The assay was operated in the dark. New system was applied. Take about 20mg of this product, precision weighing, put it in 50ml measuring flask, add appropriate amount of mobile phase, shake to dissolve and dilute to the scale, shake well, take 2ml, put it in 10ml measuring flask, dilute to the scale with mobile phase, shake well, take 20 u1 as the test solution, inject it into the liquid chromatograph, record the chromatogram, and take an appropriate amount of the reference substance of BIS-hydroxynaphthalate, precision weighing, the same method for determination. According to the external standard method to calculate the peak area of thiazine, that is.
Last Update：2022-01-01 11:33:21
Early Bird - Category
Authoritative Data Verified Data
anthelmintic drug.
Last Update：2022-01-01 11:33:21
Early Bird - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:33:22
Early Bird - Bis (hydroxynaphthalic acid) thiopyrimidine tablets
Authoritative Data Verified Data
This product contains dihydroxynaphthalate thiopyrimidine (C11H14N2S • C23H1606) should be 93.0% ~ 107.0% of the label amount.
trait
This product is a light yellow tablet.
identification
take an appropriate amount of fine powder of this product (equivalent to about 40mg of BIS-hydroxynaphthalate thiazine), and add 20ml of dioxane-0.1% concentrated ammonia solution (1: 1) to dissolve bis-hydroxynaphthalate thiazine, filter; Take 5ml of filtrate and add 2ml of dilute hydrochloric acid to form yellow precipitate; Take 10ml of filtrate and evaporate, add 1ml of sulfuric acid to the residue, shake, and the solution will appear red.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
operation in the dark. Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to 20mg of BIS-hydroxynaphthalic acid thiazine), put in 100ml Brown measuring flask, add dioxane-0.1% concentrated ammonia solution (1:l)8ml, shake to dissolve the BIS (hydroxynaphthalate) thiazine, dilute to the scale with hydrochloric acid solution (9-1000), shake, filter, precisely take 5ml of continued filtrate, put it in a 50ml brown measuring flask, dilute it with hydrochloric acid solution (9-1000) to the scale, shake it well, and measure it according to UV-Vis spectrophotometry (General rule 0401 ), the absorbance was measured at a wavelength of 311nm, and the absorption coefficient of C11H14N2S · C23H16O6 was calculated to be 313.
category
thiopyrimidine isobisonaphthalate.
specification
0.3g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:33:22
Early Bird - Bis (hydroxynaphthalic acid) thiazine granules
Authoritative Data Verified Data
This product contains dihydroxynaphthalate thiopyrimidine (C11H14N2S • C23H16O6) should be 93.0% ~ 107.0% of the label amount.
trait
This product is light yellow powder or fine particles.
identification
- taking an appropriate amount of the fine powder of this product, the same reaction was shown according to the test of item (1) and (2) under the item of dihydroxynaphthalic acid thiazine.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.
examination
should be consistent with the granules under the relevant provisions (General Principles 0104).
Content determination
operation in the dark. The contents under the item of difference in loading amount were taken and mixed uniformly. Precision weighing appropriate amount (about 20mg equivalent to dihydroxynaphthalic acid thiopyrimidine), put it in a brown measuring flask, and add 0.1% dioxane -1.5 concentrated ammonia solution (1: 1 ), shake to dissolve the dihydroxynaphthalic acid thiopyrimidine, dilute to the scale with hydrochloric acid solution (9-1000), shake well, filter, Take 5ml of continued filtrate accurately, put it in 50ml brown measuring flask, dilute to the mark with hydrochloric acid solution (9-1000), shake well, and measure the absorbance at the wavelength of 0401 NM according to UV-visible spectrophotometry (general), according to C11H14N2S. The absorption coefficient of C23Hl606 was calculated to be 313.
category
thiopyrimidine isobisonaphthalate.
specification
0.15g of BIS-hydroxynaphthalic acid thiopyrimidine per lg.
storage
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 11:33:23
Early Bird - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Pyrantel pamoate (Pyrantel Embonate) is a broad-spectrum insect repellent used to treat some parasitic infections. |
Last Update：2024-04-09 21:21:28
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